To date, the wavelengths with some of the most researched safety and efficacy are in the blue, red and near infrared spectrum between 440-950 nanometers. Research has shown this range of light to bring an increase ATP production in the mitochondria, increase ROS without DNA damage, increase Nitric Oxide induction, affect calcium ion channels assisting in osteoblast activity, and to positively affect cell regeneration factors with an increase in migration, differentiation and a decrease in apoptosis or cell death. Blue light from LEDs has long been effective in treating jaundice of newborns and more recently the anti-pathogenic effect of blue light has been shown in research with acne, MRSA, and wound healing. The Blue-Turquoise range close to 465nm has been found to support balanced circadian rhythm function which can affect sleep and mood. Red, orange and near infrared light support cell regeneration and collagen production and can have FDA clearance to treat fine lines and wrinkles. Green light is showing promise with helping to manage chronic pain signaling.